教育和工作经历

1996.9~2005.7，于中国农业大学完成本科与硕博连读；

2005.7~2007.7，为华南农业大学与广东温氏食品集团联合培养博士后；

2007.7~至今，澳门新葡官网进入澳门新莆京7906not分子生物学研究中心教师；

于2013.2~2015.1为美国纽约血液中心红系发育实验室博士后。

研究综述

主要从事疾病产生的分子机理和分子靶向治疗研究，近5年尤其致力于：利用β-地中海贫血病小鼠模型，阐述红系发育与体内铁代谢调节激素hepcidin之间复杂的双向调节关系；结合细胞和小鼠实验，展开红系发育过程中关键调节分子的发掘与功能研究，并最终期望实现相关血液疾病的分子靶向治疗。相关研究结果先后发表在Haematologica、Blood等国际学术期刊，并先后于ASH、IBIS等国际会议上作口头报告。曾先后主持国家自然科学基金、教育部新教师基金及湖南省自然科学基金各一项，作为子课题负责人参与国家863项目一项。

主要代表论文

1. Fu Y, Zhu Z, Chang H, Liu Z, Liu J, Chen H*. Comparative transcriptome analyses indicate enhanced cellular protection against FMDV in PK15 cells pretreated with IFN-γ. Gene. 2016 Jul 25; 586(2):206-15.

2. Chen H, Choesang T, Li H, Sun S, Pham P, Bao W, Feola M, Westerman M, Li G, Follenzi A, Blanc L, Rivella S, Fleming RE, Ginzburg YZ*. Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation. Haematologica. 2016 Mar;101(3):297-308.

3. Han X, Zhang J, Peng Y, Peng M, Chen X, Chen H, Song J, Hu X, Ye M, Li J, Sankaran VG, Hillyer CD, Mohandas N, An X, Liu J. Unexpected role for p19INK4d in post-transcriptional regulation of GATA1 and modulation of human terminal erythropoiesis. Blood. 2016 Nov 22. pii: blood-2016-09-739268. [Epub ahead of print]

4. Casu C, Oikonomidou PR, Chen H, Nandi V, Ginzburg Y, Prasad P, Fleming RE, Shah YM, Valore EV, Nemeth E, Ganz T, MacDonald B, Rivella S*. Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera. Blood. 2016 May 6. pii: blood-2015-10-676742.

5. Sun Z, Wang Y, Han X, Zhao X, Peng Y, Li Y, Peng M, Song J, Wu K, Sun S, Zhou W, Qi B, Zhou C, Chen H*, An X*, Liu J*. miR-150 inhibits terminal erythroid proliferation and differentiation. Oncotarget. 2015 December 15; 6(40): 43033–43047.

6. Chen HY, Zhang Q*, Yin CC, Wang CK, Gong WJ, Mei G. Detection of quantitative trait loci affecting milk production traits on bovine chromosome 6 in a Chinese Holstein population by the daughter design. J Dairy Sci. 2006 Feb; 89(2):782-90.

7. Chen H, Zhang Q *, Wang C, Shu J, Mei G, Yin C, Hu F, Xu J, Gong W, Li H, Qiu X. Mapping QTLs on BTA6 affecting milk production traits in a Chinese Holstein population. Chinese Science Bulletin. 2005 August,  50 (16):1737–1742

8. Yin CC, Chen HY, Zhang Q*. Identification of two bovine microsatellite markers in a defined region of BTA6.Anim Genet. 2005 Dec; 36(6):527-9.